The Protective Role of Strong Antioxidant Astaxanthin on Burn Wound and Burn-Induced Early Acute Kidney Injury through Abilities to Relieve Oxidative Stress and Inhibit Apoptosis by Modulating Mitochondrial-Apoptotic Pathways

Summary: Burns are skin damage caused by heat trauma or cold (frost bite). Causes include fire, hot water, electricity, chemicals, radiation, and (frostbite). This may involve subcutaneous tissue. Burn injuries associated with high incidence prevalence, risk of morbidity mortality, resource-intensive, costly. One the most common complications in burn patients is acute kidney injury (AKI). The mechanism early AKI after multifactorial, previous studies have mainly focused on oxidative stress injury, tubular apoptosis, systemic local inflammation. Previous results (from our group others) suggested that ROS-induced apoptosis play an important role development due to 24 h useful for observing changes injury. It shows it provides timeframe. Kidney function levels apoptosis. Astaxanthin (ATX) a naturally occurring carotenoid readily obtained from marine organisms stronger antioxidant effects than other carotenoids. Given critical secondary renal inflammation severe burn-induced AKI, protective ATX through its anti-inflammatory potential mechanisms action post-burn reasonable.